/* 01. Design tokens */
:root{--ink:#2B2927;--green:#315D55;--berry:#8D4D67;--amber:#C98B46;--aqua:#E2EFEC;--paper:#FAF5EA;--dust:#E8E4DF;--text:#343230;--taupe:#77716C;--white:#fff;--font-editorial:Georgia,Cambria,"Times New Roman",Times,serif;--font-sans:-apple-system,BlinkMacSystemFont,"Segoe UI",Roboto,Helvetica,Arial,sans-serif;--font-mono:ui-monospace,SFMono-Regular,Menlo,Monaco,Consolas,"Liberation Mono",monospace;--container:1200px;--space-1:.5rem;--space-2:1rem;--space-3:1.5rem;--space-4:2.25rem;--space-5:4rem;--space-6:7rem;--border:1px solid rgba(43,41,39,.18);--radius:3px;--shadow:0 12px 30px rgba(43,41,39,.08);--transition:180ms ease}
/* 02. Reset */
*,*::before,*::after{box-sizing:border-box}html{scroll-behavior:smooth}body,h1,h2,h3,p,ul{margin:0}ul{padding:0;list-style:none}img{display:block;max-width:100%}button,input{font:inherit}button{cursor:pointer}
/* 03. Base */
body{background:var(--paper);color:var(--text);font-family:var(--font-sans);font-size:16px;line-height:1.62}a{color:inherit;text-decoration:none}.container{width:min(calc(100% - 48px),var(--container));margin-inline:auto}.section{padding:var(--space-6) 0}.eyebrow,.micro-label,.sequence-step>span,.layer>span,.pathway>span,.status,.orcid{font:700 .69rem/1.3 var(--font-mono);letter-spacing:.12em;text-transform:uppercase}.eyebrow{color:var(--green);margin-bottom:1rem}.section-intro{max-width:670px;color:var(--taupe);margin-top:1rem}.button{display:inline-flex;align-items:center;justify-content:center;background:var(--ink);color:var(--white);padding:.85rem 1.25rem;border:1px solid var(--ink);font-weight:700;transition:var(--transition)}.button:hover{background:var(--green);border-color:var(--green)}.text-link{font-weight:700;border-bottom:1px solid var(--ink);padding:.35rem 0}.text-link span{color:var(--amber);margin-left:.3rem}.actions{display:flex;align-items:center;gap:1.4rem;flex-wrap:wrap}
/* 04. Accessibility */
.skip-link{position:absolute;left:1rem;top:-5rem;background:var(--amber);color:var(--ink);padding:.75rem 1rem;z-index:20}.skip-link:focus{top:1rem}a:focus-visible,button:focus-visible,input:focus-visible,summary:focus-visible{outline:3px solid var(--amber);outline-offset:3px}.sr-only{position:absolute;width:1px;height:1px;overflow:hidden;clip:rect(0,0,0,0);white-space:nowrap}.js-enabled .reveal{opacity:0;transform:translateY(18px);transition:opacity .55s ease,transform .55s ease}.js-enabled .reveal.is-visible{opacity:1;transform:none}
/* 05. Typography */
h1,h2,h3{font-family:var(--font-editorial);font-weight:400;line-height:1.08;color:var(--ink)}h1{font-size:clamp(2.8rem,5vw,5rem);letter-spacing:-.045em}h1 em{font-style:normal;color:var(--berry)}h2{font-size:clamp(2rem,3.4vw,3.5rem);letter-spacing:-.035em;max-width:860px}h3{font-size:1.55rem;letter-spacing:-.02em}.lede{font-size:1.08rem;max-width:600px;color:#5e5955}
/* 06. Layout */
.hero{padding:clamp(4.5rem,9vw,8rem) 0 5rem;background:linear-gradient(115deg,var(--paper) 68%,var(--aqua) 68%)}.hero-grid{display:grid;grid-template-columns:1.08fr .92fr;align-items:center;gap:clamp(3rem,7vw,7rem)}.hero-copy{padding:1rem 0}.hero-copy .lede{margin:1.5rem 0 2rem}.micro-label{display:block;color:var(--taupe);margin-top:4rem}.notebook-strip{padding:3.5rem 0;background:var(--ink);color:var(--paper)}.notebook-strip .eyebrow{color:var(--amber)}.notebook-strip h2{color:var(--white);font-size:clamp(1.8rem,3vw,3rem);max-width:760px}.strip-statements{display:grid;grid-template-columns:repeat(4,1fr);gap:1.5rem;margin-top:3rem}.strip-statements p{font-size:.9rem;border-top:1px solid rgba(255,255,255,.25);padding-top:.8rem}.strip-statements p::before{content:"— ";color:var(--amber)}
/* 07. Header */
.site-header{position:sticky;top:0;z-index:10;background:rgba(250,245,234,.96);border-bottom:var(--border);backdrop-filter:blur(8px)}.header-inner{min-height:76px;display:flex;align-items:center;justify-content:space-between;gap:1.5rem}.brand{width:min(350px,48vw)}.brand img{width:100%}#site-nav{display:flex;align-items:center;gap:1.2rem;font-size:.84rem;font-weight:650}#site-nav>a:not(.nav-cta){border-bottom:1px solid transparent}#site-nav>a:not(.nav-cta):hover{border-color:var(--green)}.nav-cta{background:var(--green);color:var(--white);padding:.65rem .85rem}.menu-toggle{display:none;background:transparent;border:0;padding:.5rem}.menu-toggle span{display:block;width:25px;height:2px;background:var(--ink);margin:5px}
/* 08. Hero */
/* 09. Response sequence */
.response-sequence{position:relative;padding:1.1rem 0 1.5rem}.sequence-head{display:flex;justify-content:space-between;align-items:center;font:700 .7rem var(--font-mono);letter-spacing:.1em}.sequence-head img{width:42px}.sequence-step{position:relative;width:86%;padding:1.05rem 1.2rem;margin-top:.8rem;border:var(--border);border-left:4px solid var(--green);background:var(--white);box-shadow:var(--shadow)}.sequence-step::before{content:"";position:absolute;width:10px;height:10px;border-radius:50%;left:-8px;top:18px;background:var(--amber)}.sequence-step.sensing{margin-left:7%;border-left-color:var(--amber)}.sequence-step.regulation{margin-left:14%;border-left-color:var(--berry)}.sequence-step.readout{margin-left:8%;border-left-color:var(--ink)}.sequence-step>span{color:var(--green)}.sequence-step h2{font-family:var(--font-sans);font-size:1rem;font-weight:700;letter-spacing:0;margin:.25rem 0}.sequence-step p{font-size:.78rem;color:var(--taupe);line-height:1.4}.sequence-line{position:absolute;left:1.2rem;top:5rem;height:64%;border-left:1px dashed var(--green);z-index:-1}.sequence-footer{font:700 .73rem var(--font-mono);letter-spacing:.05em;margin-top:1.5rem;color:var(--green)}.sequence-footer b{color:var(--amber)}
/* 10. Notebook strip */
/* 11. Response layers */
.responses{background:var(--dust)}.layer-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:1.2rem;margin-top:3rem}.layer{background:var(--paper);padding:1.5rem;border-top:4px solid var(--green);min-height:360px;display:flex;flex-direction:column}.layer:nth-child(2){border-color:var(--berry)}.layer:nth-child(3){border-color:var(--amber)}.layer:nth-child(4){border-color:var(--ink)}.layer>span{color:var(--taupe)}.layer h3{margin:.8rem 0}.layer p{font-size:.92rem;color:#5e5955}.layer ul{margin-top:auto;padding-top:1.5rem}.layer li{font:700 .7rem var(--font-mono);text-transform:uppercase;letter-spacing:.04em;padding:.36rem 0;border-top:var(--border)}
/* 12. Pathways */
.pathways{background:var(--aqua)}.pathway-list{margin-top:3rem;border-top:var(--border)}.pathway{display:grid;grid-template-columns:145px 1fr 1.1fr;align-items:center;gap:2rem;padding:2rem 0;border-bottom:var(--border);position:relative}.pathway::after{content:"";position:absolute;bottom:-1px;left:145px;width:20%;height:3px;background:var(--amber)}.pathway h3{font:700 1rem var(--font-mono);letter-spacing:.05em}.pathway h3 b{color:var(--berry)}.pathway p{font-size:.94rem}.pathway div{font:700 .7rem var(--font-mono);text-transform:uppercase;line-height:1.8;color:var(--green)}.pathway i{display:inline-block;width:10px;border-top:1px solid var(--green);margin:0 .5rem;vertical-align:middle}
/* 13. Notebook method */
.method-grid{display:grid;grid-template-columns:1.3fr .7fr;gap:5rem}.method-rows{margin-top:2.5rem;border-top:var(--border)}.method-rows article{display:grid;grid-template-columns:55px 1fr;gap:1rem;padding:1.25rem 0;border-bottom:var(--border)}.method-rows article>span,.principles span{font:700 .8rem var(--font-mono);color:var(--berry)}.method-rows h3{font:700 .83rem var(--font-mono);letter-spacing:.08em}.method-rows p{font-size:.94rem;margin-top:.25rem;color:#5e5955}.checklist{align-self:start;background:var(--ink);color:var(--paper);padding:2rem}.checklist .eyebrow{color:var(--amber)}.checklist h3{color:var(--white);margin-bottom:1.2rem}.checklist li{position:relative;padding:.6rem 0 .6rem 1.2rem;border-top:1px solid rgba(255,255,255,.2);font-size:.88rem}.checklist li::before{content:"+";position:absolute;left:0;color:var(--amber)}
/* 14. Researchers */
.researchers{background:var(--dust)}.contact-note{max-width:820px;border-left:3px solid var(--amber);padding:.75rem 1rem;margin:2rem 0;background:rgba(255,255,255,.48)}.contact-note p{font-size:.9rem}.researcher-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:1.1rem}.profile{background:var(--paper);padding:1.35rem;border:var(--border);display:flex;flex-direction:column;gap:.75rem;font-size:.86rem}.profile-top{display:flex;justify-content:space-between;align-items:center;font:700 .68rem var(--font-mono);text-transform:uppercase;color:var(--taupe)}.initials{display:grid;place-items:center;width:42px;height:42px;background:var(--green);color:var(--white);font:400 1rem var(--font-editorial)}.reference .initials{background:var(--berry)}.status{color:var(--green)}.reference .status{color:var(--berry)}.profile h3{font-size:1.5rem}.institution{color:var(--taupe);line-height:1.4}.orcid{color:var(--taupe);letter-spacing:.05em}.profile-tags{display:flex;flex-wrap:wrap;gap:.35rem}.profile-tags span{font:700 .64rem var(--font-mono);letter-spacing:.03em;background:var(--aqua);padding:.28rem .4rem}.profile>a{color:var(--green);font-size:.78rem;overflow-wrap:anywhere}.copy-email{align-self:start;border:1px solid var(--green);background:transparent;color:var(--green);padding:.45rem .65rem;font-size:.76rem;font-weight:700}.copy-email:hover{background:var(--green);color:var(--white)}
/* 15. Independence note */
.independence{padding:var(--space-6) 0;background:var(--ink);color:var(--paper)}.independence .eyebrow{color:var(--amber)}.independence h2{color:var(--white);margin-bottom:1.5rem}.independence p:not(.eyebrow){max-width:800px;margin-top:1rem;color:#e8e4df}
/* 16. Bench notes */
.bench-notes{background:var(--paper)}.notes-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:1rem;margin-top:2rem}.note{border:var(--border);background:var(--white)}.note details{height:100%;padding:1.25rem}.note summary{cursor:pointer;list-style:none}.note summary::-webkit-details-marker{display:none}.note summary::after{content:"+";float:right;color:var(--amber);font-size:1.5rem}.note details[open] summary::after{content:"−"}.note summary span{font:700 .67rem var(--font-mono);letter-spacing:.08em;text-transform:uppercase;color:var(--green)}.note h3{font-size:1.5rem;margin:.45rem 0}.note summary p,.note details>p{font-size:.9rem;color:#5e5955}.note details>p{border-top:var(--border);padding-top:1rem;margin-top:1rem}.note .profile-tags{margin-top:1rem}
/* 17. Search */
.search-wrap{margin-top:2.5rem;max-width:760px}.search-wrap label{font:700 .78rem var(--font-mono);letter-spacing:.07em;text-transform:uppercase}.search-wrap>div{display:flex;border-bottom:2px solid var(--ink);margin-top:.4rem}.search-wrap input{min-width:0;flex:1;border:0;background:transparent;padding:.85rem 0;outline:none}.search-wrap input::placeholder{color:var(--taupe)}#clear-search{border:0;background:transparent;color:var(--green);font-weight:700;font-size:.82rem;white-space:nowrap}.search-wrap>p{font:700 .72rem var(--font-mono);color:var(--taupe);margin-top:.65rem}#no-results{margin-top:2rem;font:400 1.5rem var(--font-editorial);color:var(--berry)}
/* 18. About */
.about{background:var(--aqua)}.about .container{display:grid;grid-template-columns:1fr 1fr;gap:5rem}.about-copy p:not(.eyebrow){max-width:650px;margin-top:1rem}.principles{border-top:var(--border)}.principles article{padding:1.2rem 0;border-bottom:var(--border)}.principles h3{font:700 1rem var(--font-mono);letter-spacing:.04em;margin:.25rem 0}.principles p{font-size:.9rem}
/* 19. Final CTA */
.final-cta{padding:var(--space-6) 0;background:var(--berry);color:var(--white)}.final-cta .eyebrow{color:#f1d3dc}.final-cta h2{color:var(--white);max-width:750px}.final-cta>div>p:not(.eyebrow){max-width:670px;margin:1rem 0 2rem}.light{background:var(--paper);color:var(--ink);border-color:var(--paper)}.light:hover{background:var(--amber);border-color:var(--amber)}.light-link{border-color:var(--white)}.light-link span{color:var(--amber)}
/* 20. Footer */
footer{background:var(--ink);color:var(--paper);padding:3rem 0 1.3rem}.footer-grid{display:grid;grid-template-columns:72px 1.4fr 1fr auto;gap:1.5rem;align-items:start}.footer-grid img{width:58px}.footer-grid h2{font-size:1.5rem;color:var(--white)}.footer-grid p{font-size:.83rem;color:#cfc8bf}.footer-grid nav{display:grid;grid-template-columns:repeat(2,max-content);gap:.35rem 1.4rem;font-size:.82rem}.footer-grid nav a:hover,.back-to-top:hover{color:var(--amber)}.back-to-top{font-size:.82rem;white-space:nowrap}.copyright{border-top:1px solid rgba(255,255,255,.18);margin-top:2rem;padding-top:1rem;font-size:.75rem;color:#cfc8bf}
/* 21. Reveal states */
/* 22. Responsive */
@media(max-width:1000px){.hero-grid{grid-template-columns:1fr;gap:3rem}.hero{background:var(--paper)}.response-sequence{max-width:650px;width:100%;margin:auto}.layer-grid{grid-template-columns:repeat(2,1fr)}.researcher-grid{grid-template-columns:repeat(2,1fr)}.method-grid,.about .container{grid-template-columns:1fr;gap:3rem}.checklist{max-width:620px}.footer-grid{grid-template-columns:58px 1fr 1fr}.back-to-top{grid-column:2}}
@media(max-width:780px){.menu-toggle{display:block}#site-nav{display:none;position:absolute;left:0;right:0;top:76px;background:var(--paper);padding:1.25rem 24px 1.5rem;border-bottom:var(--border);box-shadow:var(--shadow);align-items:stretch;flex-direction:column;gap:.8rem}#site-nav.is-open{display:flex}.nav-cta{text-align:center;margin-top:.4rem}.pathway{grid-template-columns:1fr;gap:.7rem}.pathway::after{left:0}.pathway div{padding-top:.4rem}.strip-statements{grid-template-columns:repeat(2,1fr)}.footer-grid{grid-template-columns:58px 1fr}.footer-grid nav{grid-column:1/-1}.back-to-top{grid-column:auto}}
@media(max-width:540px){.container{width:min(calc(100% - 32px),var(--container))}.section{padding:4.2rem 0}.site-header .brand{width:230px}.hero{padding-top:3.8rem}.hero-grid{gap:2.5rem}.sequence-step,.sequence-step.sensing,.sequence-step.regulation,.sequence-step.readout{width:100%;margin-left:0}.sequence-line{display:none}.sequence-footer{font-size:.62rem}.strip-statements,.layer-grid,.researcher-grid,.notes-grid{grid-template-columns:1fr}.notebook-strip{padding:3rem 0}.pathway{padding:1.5rem 0}.footer-grid{gap:1rem}.footer-grid img{width:46px}.footer-grid nav{grid-template-columns:1fr}.actions{gap:1rem}.button{width:100%}.text-link{width:max-content}}
/* 23. Reduced motion */
@media(prefers-reduced-motion:reduce){html{scroll-behavior:auto}.js-enabled .reveal{opacity:1;transform:none;transition:none}*,*::before,*::after{transition-duration:.01ms!important;animation-duration:.01ms!important;scroll-behavior:auto!important}}